Hand radiographs, PA views of the hands are performed at baseline and years 3 and 5 during the study.This analysis was limited to the baseline radiographs.

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– San Diego, CA) with a titer of Association between genotypes and dichotomous phenotypes for CCP, RF and erosive RA at baseline were assessed with logistic regression models adjusting for age, sex, and disease duration.

Association between genotype and age at diagnosis of RA phenotype was assessed with general linear models adjusting for sex.

The study was approved by the Partners Institutional Review Committee.

Blood was collected at the baseline visit for genotyping.

Rheumatoid factor testing was performed by immunoturbidimetric technique on the Cobas Integra 700 analyzer (Roche Diagnostics -Indianapolis, IN), using reagents and calibrators from Roche.

Anti-cyclic citrullinated peptide antibodies (CCP) were measured using a second generation ELISA assay (Inova Diagnostics, Inc.A total of 689 RA patients from the Brigham RA Sequential Study (BRASS) were genotyped for HLA-SE, PTPN22 (rs2476601) and CTLA4 (rs3087243).Association between genotypes and CCP, rheumatoid factor (RF) erosive phenotypes and age at diagnosis were assessed with multivariable models adjusting for age, sex and disease duration.We also found evidence for associations between HLA-SE, and PTPN22 and earlier age at diagnosis.Since HLA-SE is associated with erosive phenotype in unconditional analysis, but is not significant after conditioning on CCP, this suggests that CCP is in the causal pathway for predicting erosive phenotype. Association between genotypes and CCP, RF erosive phenotypes and age at diagnosis were assessed with multivariable models adjusting for age, sex, and disease duration.HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis (RA).