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Functional imaging methods such as Positron Emission Tomography (PET) and functional Magnetic Resonance Imaging (f MRI) have contributed inestimably to the understanding of physiological cognitive processes in the brain in the recent decades.

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Function (in philosophy): “A normative relation of objects or events to their use or consequences” (Function.

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It was therefore obvious to apply these methods to evaluate pathomechanisms of cognitive dysfunction in disorders such as Alzheimer’s disease (AD) as well.

One of the most dominant symptoms of AD is the impairment of memory.

In this context, the term “memory” represents a simplification and summarizes a set of complex cognitive functions associated with encoding and retrieval of different types of information.

A number of imaging studies assessed the functional changes of neuronal activity in the brain at rest and also during performance of cognitive work, with regard to specific characteristics of memory decline in AD.

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